Multiscale modeling of cellular systems in biology

Multiscale Modeling of Cellular Systems in Biology

Here we review eight different multiscale modeling efforts dealing with cellular systems in biology. The first two models focus on collagen based tissue, one dealing with the biomechanical properties of the tissue and the other focusing on how the dermis is remodeled in scar tissue formation. The next two models deal with first avascular tumor growth and then the role of the vasculature in tumo...

Multiscale Modeling of Bone Healing: Toward a Systems Biology Approach

Bone is a living part of the body that can, in most situations, heal itself after fracture. However, in some situations, healing may fail. Compromised conditions, such as large bone defects, aging, immuno-deficiency, or genetic disorders, might lead to delayed or non-unions. Treatment strategies for those conditions remain a clinical challenge, emphasizing the need to better understand the mech...

Emerging Challenges in Multiscale Modeling in Biology.

Multiscale Spatial Computational Systems Biology

This report documents the program and the outcomes of Dagstuhl Seminar 14481 “Multiscale Spatial Computational Systems Biology”. This seminar explored challenges arising from the need to model and analyse complex biological systems at multiple scales (spatial and temporal), which falls within the general remit of Computational Systems Biology. A distinguishing factor of the seminar was the mode...

BioModel engineering for multiscale Systems Biology.

We discuss some motivational challenges arising from the need to model and analyse complex biological systems at multiple scales (spatial and temporal), and present a biomodel engineering framework to address some of these issues within the context of multiscale Systems Biology. Our methodology is based on a structured family of Petri net classes which enables the investigation of a given syste...